There is no known way to intentionally reduce the glomerular filtration rate (GFR). GFR measures kidney function, and a low GFR indicates impaired filtration. Chronic conditions such as kidney disease, diabetes, high blood pressure, and heart failure can lower GFR. Certain medications, including diuretics, NSAIDs, aminoglycosides, and chemotherapy drugs, can also affect it. Regular monitoring through blood tests is important for those at risk.