Wolves can kill mountain lions, although such incidents are rare. Wolves usually hunt in packs and are often larger and more powerful, giving them an advantage in confrontations. Mountain lions are solitary and rely on ambush, using sharp teeth and claws, but they are unlikely to escape unscathed if surrounded by a wolf pack.
In general, wolves and mountain lions coexist across much of North America, competing for food and territory but rarely engaging in direct conflict.